解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Ampelopsis sinica root (ASR) is a known hepatoprotective folk traditional Chinese medicine. The anti‑hepatoma activity of ethyl acetate extract from A. sinica root (ASRE) in vitro and in vivo and its possible mechanism were explored. This study was designed to investigate cytotoxicity by MTT assay, induction of apopto...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5504
更新日期:2017-04-01 00:00:00
abstract::The number of new lung cancer cases diagnosed yearly is high, and the mortality rate has not substantially declined. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, and adenocarcinoma accounts for the largest proportion of NSCLC. Currently, platinum-based combined chemotherapy, particularly ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5505
更新日期:2017-04-01 00:00:00
abstract::Squamous cell carcinoma (SCC) is histologically the most prominent type of cervical cancer. There is accumulating evidence suggesting that microRNAs (miRNAs) play important regulatory roles in the biological processes of cervical squamous cell carcinoma (CSCC). Deciphering the miRNA regulatory network in CSCC could de...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5372
更新日期:2017-03-01 00:00:00
abstract::The characteristics of ovarian cancers that showed low activation of glycolysis were investigated. Using medical records of patients with ovarian cancers who had undergone fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) prior to their primary surgery at the University of Tokyo Hospital...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5398
更新日期:2017-03-01 00:00:00
abstract::Although improvements in the chemotherapy modalities for pancreatic cancer have been realized, pancreatic cancer remains one of the most lethal malignancies. New-generation cancer immunotherapy methods, such as blocking of the PD-1/PD-L1 pathway, are consistently being investigated to improve the survival of pancreati...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5399
更新日期:2017-03-01 00:00:00
abstract::Breast cancer is one of the most malignant diseases world-wide and it ranks the first among female cancers. Masses of intrinsic and extrinsic factors, especially the inflammatory factors can lead to breast cancer. Aberrant activation and accumulation of key molecules can lead to inflammation associated carcinogenesis....
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5393
更新日期:2017-03-01 00:00:00
abstract::Expression of miR-365 has been reported to be downregulated in hepatocellular carcinoma (HCC). However, the biological function and underlying mechanism of miR-365 in HCC growth and metastasis remain unclear. The aim of the present study was to explore the role of miR-365 in HCC progression. We found that miR-365 expr...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5423
更新日期:2017-03-01 00:00:00
abstract::Identification of safe, effective radiosensitizing agents is urgently needed to improve the outcome of radiotherapy in nasopharyngeal cancer (NPC). In this study, we assessed the ability of the polyphenol resveratrol to act as a radiosensitizer in vitro and in vivo. CNE-1 cells were treated with 50 µM resveratrol for ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5413
更新日期:2017-03-01 00:00:00
abstract::The aim of the present study was to screen gastric cancer (GC) tissue and adjacent tissue for differences in mRNA and circular (circRNA) expression, to analyze the differences in circRNA and mRNA expression, and to investigate the circRNA expression in gastric carcinoma and its mechanism. circRNA and mRNA differential...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5415
更新日期:2017-03-01 00:00:00
abstract::DEK, a transcription factor, is involved in mRNA splicing, transcriptional control, cell division and differentiation. Recent studies suggest that DEK overexpression can promote tumorigenesis in a wide range of cancer cell types. However, little is known concerning the status of DEK in pancreatic ductal adenocarcinoma...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5302
更新日期:2017-02-01 00:00:00
abstract::Transforming growth factor-β1 (TGF-β1) signaling has been shown to play a critical role in the development of epithelial-mesenchymal transition (EMT). PAI-1 is one of the most important target genes in the TGF-β/Smad signaling pathway, which can hinder the degradation of ECM composition and may promote cell invasion a...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5292
更新日期:2017-02-01 00:00:00
abstract::The present study aimed to evaluate a previously reported predictive formula of output-limiting symptoms induced by radiofrequency (RF) to determine the efficacy of this neoadjuvant chemoradiation (NACR) and concurrent RF thermal therapy. The present study included 81 consecutive patients with confirmed diagnoses of r...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5300
更新日期:2017-02-01 00:00:00
abstract::Arginine is a critical amino acid in specific cancer types including hepatocellular carcinoma (HCC) and melanoma. Novel molecular mechanisms and therapeutic targets in arginine metabolism-mediated cancer formation await further identification. Our laboratory has previously demonstrated that arginine metabolic enzyme a...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5334
更新日期:2017-02-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the most common form of adult liver cancer and accounts for approximately 90% of all cases of primary liver cancer annually. Rhotekin (RTKN), which functions as a cancer promoter, can be frequently detected in many human cancers, including gastric cancer, colorectal carcinoma and blad...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5290
更新日期:2017-02-01 00:00:00
abstract::Epidemiologic studies indicate the use of either statins or aspirin have beneficial effects in prostate cancer patients. The present study was undertaken to evaluate the effects and mechanisms of atorvastatin and aspirin alone or in combination in human prostate cancer cells cultured in vitro and grown as xenograft tu...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5353
更新日期:2017-02-01 00:00:00
abstract::Glioma is the most frequent and aggressive primary tumor of the brain in humans. Over the last few decades, significant progress has been made in early detection and multi-mode treatments, but the prognosis of gliomas is still extremely poor. MicroRNAs are endogenously expressed non-coding, single strand and short RNA...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5320
更新日期:2017-02-01 00:00:00
abstract::Osteosarcoma (OS) is a common primary malignancy in children and adolescents with relative high survival rate after chemotherapy. While the toxicity of chemotherapy and personalized different response to chemotherapy makes it difficult for the selection of therapeutics and improvement of diagnosis. In this study, we c...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5324
更新日期:2017-02-01 00:00:00
abstract::microRNAs (miRNAs), a class of small non-coding RNA molecules, can regulate gene expression by interacting with the 3'-untranslated regions (3'UTR) of target genes and influence various biological processes. We investigated the potential role of miR-24-3p in the development of bladder cancer by regulating DEDD, a memb...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5326
更新日期:2017-02-01 00:00:00
abstract::Invasiveness and metastasis may seriously affect the prognosis of small cell lung cancer (SCLC). In the present study, we analyzed the effects and inherent mechanisms of action of polysialic acid-modified neural cell adhesion molecule (NCAM) on the invasive and metastatic potential of SCLC. Gene transfection and short...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5279
更新日期:2017-01-01 00:00:00
abstract::Chronic hepatitis B virus (HBV) infection is a leading cause of liver cirrhosis and cancer. Among the pathogenic factors of HBV, HBV X protein (HBx) is attracting increased attention. Although it is documented that HBx is a multifunctional regulator that modulates cell inflammation and apoptosis, the exact mechanism r...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5225
更新日期:2017-01-01 00:00:00
abstract::Casein kinase 2 interacting protein-1 (CKIP-1; also known as PLEKHO1) is involved in regulating many processes such as cell proliferation, differentiation and apoptosis. CKIP-1 also plays an important role in many types of cancer, such as colon, breast cancer and human osteosarcoma. In the present study, we found that...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5233
更新日期:2017-01-01 00:00:00
abstract::Arginine and nitric oxide (NO) are important mediators of tumorigenesis in various types of cancer. Dysregulation of NO content by argininosuccinate lyase (ASL) has been previously demonstrated to inhibit the proliferation of liver and breast cancer cells. However, the function of ASL in colon cancer is not well defin...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5221
更新日期:2017-01-01 00:00:00
abstract::New therapeutic strategies are needed for colorectal cancer (CRC) treatment. MicroRNAs are involved in cancer‑pertinent cellular processes, including chemoresistance. As miR‑302a is an embryonic stem cell‑specific microRNA, studies on miR‑302a have focused on its role in human stem cells. Studies analyzing miR‑302 fun...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5237
更新日期:2017-01-01 00:00:00
abstract::Recent studies have shown that miRNAs have potent abilities to activate gene expression by targeting promoter elements, a phenomenon known as RNA activation (RNAa). In the present study, we identified a new endogenous miR-3619-5p which was decreased in prostate cancer tissues and cells compared to corresponding normal...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5250
更新日期:2017-01-01 00:00:00
abstract::Aberrant expression of microRNAs has been identified as regulators of biological processes of hepatocellular carcinoma (HCC) by negatively regulating protein-coding mRNAs. Several studies have demonstrated that miR-638 expression was dysregulated in various human cancers. However, the clinical significance and underly...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5273
更新日期:2017-01-01 00:00:00
abstract::Tumor angiogenesis, growth and metastasis are three closely related processes. We therefore explored the effects of (-)-oleocanthal (OC) on the three processes in melanoma and investigated underlying mechanisms. In vitro, OC suppressed proliferation, migration, invasion and induced apoptosis in melanoma cells. In addi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5270
更新日期:2017-01-01 00:00:00
abstract::As part of the efforts to drug repurposing, some HIV drugs have recently been identified to exert anticancer effects. Selected nucleoside analogues of nucleosidic reverse-transcriptase inhibitors (NRTIs) have been shown to interfere with RNA transcription of HI viruses as well as with the replication of DNA in cancer ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5243
更新日期:2017-01-01 00:00:00
abstract::Inhibition of epidermal growth factor receptor (EGFR) signalling has emerged as a new treatment strategy for oral squamous cell carcinoma (OSCC). Previously, we found that loss of EGFR expression in OSCC was associated with epithelial-mesenchymal transition (EMT), and may have functional implications with regard to re...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5189
更新日期:2016-12-01 00:00:00
abstract::Long non-coding RNA growth arrest-specific 5 (GAS5) was reported to be aberrantly expressed in various types of cancers. However, the role of GAS5 in the evolution and progression of ovarian cancer remains elusive. In the present study, we aimed to investigate the cellular function and clinical significance of GAS5 in...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5200
更新日期:2016-12-01 00:00:00
abstract::MicroRNA-455 (miR-455) has been considered as a novel cancer-related miRNA and dysregulated expression frequently occurs in various human types of cancer. However, its clinical significance, its biological function and the underlying molecular signaling involved in hepatocellular carcinoma (HCC) remain to be elucidate...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5139
更新日期:2016-12-01 00:00:00
abstract::MicroRNA (miRNA) is a type of endogenous non‑coding RNA implicated in various cellular processes. Studies have shown that miR-124 is involved in the malignant progression of cancer, but little is known concerning its potential role in breast cancer. Therefore, the purpose of this study was to conduct a functional anal...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5163
更新日期:2016-12-01 00:00:00
abstract::Formation of cancer stem cells (CSCs) and increased cells proliferation are involved in tumorigenesis, tumour recurrence and therapy resistance and microRNA is essential for the development of the biological traits of CSCs and the increased cells proliferation. Studying molecular mechanism of tumorigenesis, tumour rec...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5149
更新日期:2016-12-01 00:00:00
abstract::Gastroenteropancreatic neuroendocrine tumors (GEP‑NETs) are relatively uncommon. Unfortunately, epidemiological studies on the incidence of GEP‑NETs worldwide have reported a marked increase in the detection of these tumors. Although they often exhibit relatively indolent clinical courses, GEP‑NETs have the potential ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5170
更新日期:2016-12-01 00:00:00
abstract::The endoplasmic reticulum (ER) is a membranous network within cells that is important for several cellular functions including translation and folding of secretory and membrane proteins, lipid biogenesis and sequestration of Ca2+. Disruption of ER structure might affect the normal physiology of the cells. In yeast, ex...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5209
更新日期:2016-12-01 00:00:00
abstract::The objective of this study was to investigate the effect of silencing gene protein phosphatase 1H (PPM1H) on malignant phenotype of human pancreatic cancer cell line BxPC-3. In order to explore the function of PPM1H in pancreatic cancer cells, real-time PCR and western blotting were used to detect the expression of P...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5065
更新日期:2016-11-01 00:00:00
abstract::Cyclin Y (CCNY) is a newly identified PFTK1 interacting protein and has been found to be associated with the proliferation and tumorigenesis of human non-small cell lung cancer. In the present study, we analyzed the expression levels of CCNY in 65 cases of breast cancer (BC) tissues and in four BC cell lines, BT-474, ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5126
更新日期:2016-11-01 00:00:00
abstract::Sesquiterpene lactones have been confirmed to have potential antitumor activity. Here, we demonstrated that Eupalinolide O (EO), a novel sesquiterpene lactone isolated from Eupatorium lindleyanum DC., showed significant anticancer activity against human MDA-MB-468 breast cancer cells. The cytotoxicity induced by EO wa...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5115
更新日期:2016-11-01 00:00:00
abstract::Membrane-associated RING-CH (MARCH) belongs to the family of RING-CH type E3 ubiquitin ligases. MARCH1 ubiquitinates and downregulates MHC class II expression in APCs and targets major players of the immune system. However, the role of MARCH1 in ovarian cancer has not been elucidated. The present study investigated th...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5076
更新日期:2016-11-01 00:00:00
abstract::Esophageal squamous cell carcinoma (ESCC) is the predominant subtype of human esophageal cancer in East Asia. In the present study, we explored the tumor suppressive function of microRNA-181d (miR-181d) in ESCC. Quantitative RT-PCR was used to assess gene levels of miR‑181d in both ESCC cell lines and clinical samples...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5028
更新日期:2016-10-01 00:00:00
abstract::The incidence and associated mortality of melanoma continues to increase worldwide. At present, there is no curative therapy for advanced stage of melanoma. It is necessary to find new indicators of prognosis and therapeutic targets. Increasing evidence shows that miRNA can provide potential candidate biomarkers for m...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5020
更新日期:2016-10-01 00:00:00